Activities

The mission of the Institute is being accomplished by various activities as under:

• Research and Development
• Pursuit of programmes of Education
• Technology Transfer
• Advanced Training
• Establishing linkages between Government, University, Research Laboratories and Industry
• Concentrating on Export Product/Services and providing turn-key consultancy

ACADEMIC PROGRAMMES

The four main constituent units visualised are:

• An Innovation Laboratory
• An R&D Incubation Centre
• A Learning Centre
• A Commercialization Centre

EVENTS AND WORKSHOPS

These workshops are designed as an brainstorming exercise for faculty members and students of
various colleges, Universities and Research institutes aiming at using cutting edge technologies
and applied research apart from opportunity to present, discuss theoretical approaches and their
practical applications. Participants being addressed by renowned technologists, scientists,
administrators associated with Malkolak Knowledge Centre.

Guest lectures and worskhops organised -

• SAY NO TO DROUGHT - A one-day workshop on “Drought Management”

• THE SANCTIFICATION OF WATER - A one-day workshop on “Rain Water Harvesting”

• NANO TECHNOLOGICAL OPTIMIZATION AND ADAPTATION IN DEVELOPING NEW DIMENSIONS FOR POTTERY INDUSTRY

• RENEWABLE ENERGY 

• GUEST LECTURE ON “ADVANCING FRONTIERS OF BIOTECHNOLOGY” by Dr. K. Muralidaran (Retd. Agriculture Scientist, IARI).

• GUEST LECTURE ON ROBOTICS: TODAY AND TOMORROW’ by Mr. Sudhir Sanna, M.S. (USA), M. Tech. (India)

• GUEST LECTURE ON INDIAN PHARMACEUTICAL INDUSTRY: PERSPECTIVES

• GUEST LECTURE ON IDENTIFICATION OF NOVEL GENES IN HUMAN GENETIC DISORDERS

• GUEST LECTURE ON INHIBITION OF SMAD 2/3 SIGNALING PATHWAY BY ACE-536 MITIGATES INEFFECTIVE ERYTHROPOIESIS IN Β-THALASSEMIA AND MYELODYSPLASTIC SYNDROMES

• GUEST LECTURE ON ENDOGENOUS ANTI ANGIOGENIC PROTEINS FOR THE TREATMENT OF CANCER AND NEOVASCULAR DISEASES

UPCOMING THEMES FOR WORKSHOP
 Basics in Biochemical and Molecular Biology theory and techniques.
 Basic Immunology theory and techniques
 Fundamentals of Genomics and Proteomics
 Biotechnology Management & Entrepreneurship development
 Molecular Databases
 Gene to Disease therapy
 New insight in therapeutic research
 Thread between Biology and Informatics
 Emerging strategies’ in insilico drug discovery

PRODUCTS AND INNOVATIONS

PROJECTS COMPLETED

1. Mutant Phage Library Technology for rapid diagnostics: Mutant Phage Library Technology for rapid diagnostics of pathogenic S.aureus strains: The concept of fast diagnosis requires the development of appropriate instrumentation that will enable to process the diagnostic sample in field conditions. It is possible to develop a device that can handle practically any diagnostic sample, and that can be used for the diagnosis of practically any pathogen (i.e.. bacteria, viruses, immune sera, toxins etc., Evaluate the above described mutant phage library technology to classify Staphylococcus aureus strains according to their clinical and epidemiological pathogenicity. Bacterial isolates are obtained from extensive field surveys. Pathogenic characteristics will be established on the basis of inflammatory response in the host (somatic cell counts) and antibiotic susceptibility pattern of the isolates.

2. Sea-ranching for stock enhancement of the Indian horseshoe crabs and characterization of peri-vitelline fluid of its fertilized eggs for biomedical uses

The most important achievement of the project was releasing of a good number of healthy larvae of T. gigas to their natural habitat. These larvae were produced under simulated conditions at the laboratory. It is now expected that the lost population of the horseshoe crab will be restored to some extent. A total number of approximately 105,948 larvae were produced successfully. Anti-bacterial activities were assessed against six strains of pathogenic bacterial strains. The anti-bacterial compound isolated from PVF and egg membrane of the horseshoe crab will be a potential product for chemical synthesis that will be useful commercially for biomedical applications, especially for treating diseases caused by multi drug resistant and extreme drug resistant bacterial strains.

3. Commercialization of anti-viral compounds - New Lead molecules for Malaria

The crude extract prepared by the enzyme-acid hydrolyzing process from a marine organism showed initially a potent anti-malarial activity, at least when examined for in vitro cultures of Plasmodium falciparum in human erythrocytes. This led to an effort towards isolating and characterizing the molecular entity(ies) responsible for anti-malarial activity. An activity-guided fractionation strategy was followed in present research where a variety of chromatographic steps were employed. These included HPLC using a range of columns (hydrophobic, selective absorption, ion-exchange etc.), preparative thin layer chromatography and gel filtration chromatography. Selective enrichment of activity was monitored at every step using P. falciparum culture for in vitro studies. This effort has resulted in eventually identifying two compounds that independently showed anti-malarial activity. This was followed by structure elucidation of the chemical structure of these two compounds. The elucidated structures were also independently validated and found potent.